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Neurology Xagena

A research presented at the International Stroke Conference ( ISC ) and published in The New England Journal of Medicine ( NEJM ) found that the addition of the Solitaire Device stent thrombectomy pro ...


Data from a pre-specified interim analysis of PRIME, the phase 1b study of Aducanumab ( BIIB037 ) were presented at the 12th International Conference on Alzheimer's and Parkinson's Diseases and Relate ...


Teva Pharmaceutical has announced the successful completion of its Phase IIb migraine prevention program with positive top-line results from a Phase IIb study evaluating the efficacy, safety and toler ...


Hemicrania continua is a strictly unilateral, continuous headache, typically mild to moderate in severity, with severe exacerbations commonly accompanied by cranial autonomic features and migrainous s ...


The purpose of a study was to monitor weight regain after therapy discontinuation in patients with migraine experiencing weight loss during Topiramate ( Topamax ) treatment. Patients with migraine ...


Hemiplegic migraine is a particularly severe form of the disease that often evolves to a debilitating chronic illness that is resistant to commonly available therapies. Peripheral neurostimulation h ...


The FDA ( Food and Drug Administration ) has approved Watchman Left Atrial Appendage Closure Device. The Watchman Device offers a new stroke risk reduction option for high-risk patients with non-valvu ...


The FDA ( Food and Drug Administration ) has cleared for marketing the ENROUTE Transcarotid Neuroprotection System ( ENROUTE TNS ), for use during a minimally invasive procedure to restore normal bloo ...


In patients with Alzheimer's disease ( AD ), the relationship between cognitive and functional progression is not fully understood; however, functional decline has been postulated to follow cognitive ...


The Food and Drug Administration ( FDA ) has approved Duopa ( Carbidopa and Levodopa ) enteral suspension for the treatment of motor fluctuations for people with advanced Parkinson's disease. Duopa is ...


Natalizumab ( Tysabri ) has shown its efficacy in reducing multiple sclerosis ( MS ) relapses and progression of disability; however, it has been associated with an increased risk of developing progre ...


Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In a study, digital subtraction angiography ( DSA ) was used to measure the absolute cerebral ...


In a 6-month double-blind, placebo-controlled study of Parkinson's disease patients with motor fluctuations, Safinamide ( Xadago ) 50 and 100 mg/die significantly increased ON-time without increasing ...


Previous reports indicate an association between Epstein-Barr virus ( EBV ) antibody levels and multiple sclerosis ( MS ) disease activity, but the results have been conflicting. The objective of a ...


Psychiatric disorders are known to be prevalent in multiple sclerosis ( MS ). The objective of this paper was to study comorbidity between multiple sclerosis and bipolar disorder, schizophrenia and de ...


Statin use during hospitalization is associated with improved survival and a better discharge disposition among patients with ischemic stroke. It is unclear whether inpatient statin use has a similar ...


The benefit of statins in patients with acute aneurysmal subarachnoid haemorrhage is unclear. A study aimed to determine whether Simvastatin ( Zocor ) 40 mg could improve the long-term outcome in pati ...


Previous reports have indicated an association between Epstein-Barr virus ( EBV ) antibody levels and multiple sclerosis ( MS ) disease activity, but the results have been conflicting. The objectiv ...


Subcutaneous Pegylated interferon ( Peginterferon ) beta-1a ( Plegridy ) has been developed for treatment of relapsing multiple sclerosis, with less frequent dosing than currently available first-line ...


It has been demonstrated that the internal jugular vein may exhibit abnormalities classified as truncular venous malformations ( TVMs ). The investigation of possible morphological and biochemical ano ...


Traumatic brain injury ( TBI ) is a major cause of death and disability worldwide. Progesterone has been shown to improve neurologic outcome in multiple experimental models and two early-phase trials ...


Levodopa is effective for the motor symptoms of Parkinson's disease ( PD ), but is associated with motor fluctuations and dyskinesia. Many patients require add-on therapy to improve motor fluctuations ...


The baseline severity of cervical dystonia is shown in short segments, along with outcomes after 6 months of pallidal neurostimulation in three study participants. Cervical dystonia is managed mainly ...


Patients who develop relapsing-remitting multiple sclerosis ( MS ) present with a first clinical demyelinating event. In this double-blind, multicentre, randomised, phase 3 study, ORACLE MS, researche ...


A study has evaluated the effect of slow-release ( SR ) Fampridine ( Fampyra ) on multiple outcome measures reflecting different domains, and to compare the responsiveness of the Six Spot Step Test ( ...


No available treatments slow or halt progression of multiple system atrophy, which is a rare, progressive, fatal neurological disorder. In a mouse model of multiple system atrophy, Rifampicin ( Rifadi ...


Teriflunomide ( Aubagio ) is a once-daily oral immunomodulator approved for the treatment of relapsing-remitting multiple sclerosis. Researchers have assessed the efficacy and safety of Teriflunomi ...


Whether initial treatment for Parkinson's disease should consist of Levodopa, dopamine agonists, or monoamine oxidase type B inhibitors ( MAOBI ) is uncertain. Researchers aimed to establish which o ...


The Committee for Medicinal Products for Human Use ( CHMP ) has recommended that the European Commission approve the use of Xadago ( Safinamide ) as add-on to L-dopa alone or in combination with dopam ...


The lack of prospective trial data comparing certain multiple sclerosis therapies could be addressed with observational research. Researchers have investigated outcomes of Natalizumab ( Tysabri ) v ...


A study has evaluated the efficacy and safety of subcutaneous Peginterferon beta-1a ( Plegridy ) over 2 years in patients with relapsing-remitting multiple sclerosis in the ADVANCE study. Patients ...


Up to 70% of Parkinson’s disease ( PD ) patients experience sleep problems that negatively impact their quality of life. Some patients have disturbed sleep/wake patterns such as difficulty falling asl ...


Deep brain stimulation ( DBS ) has become a well-recognized nonpharmacologic treatment that improves motor symptoms of patients with early and advanced Parkinson’s disease. Evidence now indicates th ...


Frontotemporal dementia ( FTD ) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes ...


Progesterone has been associated with robust positive effects in animal models of traumatic brain injury ( TBI ) and with clinical benefits in two phase 2 randomized, controlled trials. Researchers ...


The FDA ( Food and Drug Administration ) has approved Lemtrada ( Alemtuzumab ) for the treatment of patients with relapsing forms of multiple sclerosis ( MS ). Because of its safety profile, the use o ...


Migraine remains poorly treated, with few effective preventive drugs available. Researchers assessed the safety and efficacy of LY2951742, a fully humanised monoclonal antibody to CGRP ( calcitonin ge ...


It is known that the risk of stroke in patients with traumatic brain injury might be increased. However, the relationship between mild traumatic brain injury and ischemic stroke has never been establi ...


Duchenne muscular dystrophy is caused by dystrophin deficiency and muscle deterioration and preferentially affects boys. Antisense-oligonucleotide-induced exon skipping allows synthesis of partially f ...


Phase IIa clinical trial data on ATL1102 were published in the medical journal Neurology. The article highlights the successful outcomes of the randomised, double-blind, placebo-controlled study in 77 ...


In preclinical studies, Davunetide promoted microtubule stability and reduced tau phosphorylation. Because progressive supranuclear palsy ( PSP ) is linked to tau pathology, Davunetide could be a trea ...


Teriflunomide ( Aubagio ) is an oral disease-modifying therapy approved for treatment of relapsing or relapsing–remitting multiple sclerosis. Researchers aimed to provide further evidence for the sa ...


The evaluation of therapeutic choices is needed after 24 doses of Natalizumab ( Tysabri ) in patients with multiple sclerosis ( MS ). A study has evaluated the effect of therapeutic choices on the me ...


No reliable treatment options are known for progressive multifocal leukoencephalopathy with underlying immunodeficiency. Researchers have described successful compassionate use of in a patient with ...


Five-year results from the ENDORSE phase 3 extension study have shown Dimethyl fumarate ( Tecfidera ) provides strong and sustained efficacy in a broad range of people living with relapsing-remitting ...


In a 6-month double-blind, placebo-controlled study of Parkinson's disease patients with motor fluctuations, Safinamide 50 and 100 mg/d significantly increased ON-time without increasing dyskinesia. ...


Many of those who are genetically predisposed to develop atrial fibrillation, which dramatically raises the risk of stroke, can be identified with a blood test. This is shown by new research from Lund ...


Interim results from the second year of the extension study of Alemtuzumab ( Lemtrada ) for multiple sclerosis were presented at the European Committee for Research and Treatment in Multiple Sclerosis ...


Increasing evidence suggests that seizures and status epilepticus can be immune-mediated. Researchers aimed to describe the clinical features of a new epileptic disorder, and to establish the target ...


A follow-up study of patients with Parkinson’s disease ( PD ) who participated in an earlier proof of concept clinical trial using Exenatide showed that improvements persisted twelve months after disc ...



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