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Neurology Xagena

Verubecestat is an investigational small molecule inhibitor of the enzyme beta-site amyloid precursor protein cleaving enzyme 1 ( BACE1 ) for the potential treatment of Alzheimer’s disease. A resear ...


New efficacy data for investigational Cladribine tablets were presented at the 32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis ( ECTRIMS ), in London. The fi ...


New results from the REGAIN study, a global, placebo-controlled phase 3 registration trial of Eculizumab ( Soliris ) in patients with refractory generalized myasthenia gravis ( gMG ), were presented a ...


A reduction of cardiovascular events has been reported in phase 2 and 3 trials of the proprotein convertase subtilisin kexin 9 ( PCSK9 ) inhibitors Alirocumab and Evolocumab. Researchers have inve ...


New research from researchers based at The Westmead Institute in Sydney has drawn a link between the genetic and environmental circumstances of multiple sclerosis, which affects 2.1 million people wor ...


Traumatic brain injury with a loss of consciousness may be associated with later development of Parkinson's disease but not Alzheimer's disease or incident dementia, according to a study conducted at ...


The results from the phase 2 SYNERGY study evaluating Opicinumab ( anti-LINGO-1 ), an investigational, fully human monoclonal antibody being developed as a potential neuroreparative therapy in people ...


The pathogenesis of rosacea is unclear, but increased matrix metalloproteinase target tissue activity appears to play an important role. Parkinson disease and other neurodegenerative disorders also di ...


Northwestern Medicine researchers have discovered a new cause of Parkinson's disease, mutations in a gene called TMEM230. This appears to be the third gene definitively linked to confirmed cases of th ...


A promising approach to neurotherapeutics involves activating the nuclear-factor-E2-related factor 2 ( Nrf2 ) / antioxidant response element signaling, which regulates expression of antioxidant, anti- ...


Runs of premature atrial complexes ( PACs ) are common in stroke patients and perceived to be clinically insignificant, but their prognostic significance is unclear. A study has investigated the ass ...


A study has evaluated the efficacy and tolerability of intravenous Lacosamide ( LCM-iv ) under routine conditions in daily clinical practice as a prospective registry. Patients with any type of sei ...


Few studies have systematically investigated insomnia in adults with epilepsy. Researchers have performed a prospective cross-sectional investigation of the prevalence, severity, and comorbidities ...


White matter is diffusely altered in tuberous sclerosis complex ( TSC ), and these alterations appear to be more evident in subjects with a more severe neurologic phenotype. However, little is known ...


Adipokines, especially leptin and adiponectin, have gained increasing importance in pathophysiology of various neurological diseases including epilepsy. There are experimental data suggesting a role ...