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Risk of dementia, Parkinson's, Alzheimer's and multiple sclerosis linked to living near major roads


Living near major roads or highways is linked to higher incidence of dementia, Parkinson's disease, Alzheimer's disease and multiple sclerosis, suggests new research published in the journal Environmental Health.

Researchers from the University of British Columbia analyzed data for 678,000 adults in Metro Vancouver.
They found that living less than 50 metres from a major road or less than 150 metres from a highway is associated with a higher risk of developing dementia, Parkinson's, Alzheimer's and multiple sclerosis, likely due to increased exposure to air pollution.

The researchers also found that living near green spaces, like parks, has protective effects against developing these neurological disorders.

Neurological disorders are increasingly recognized as one of the leading causes of death and disability worldwide.
Little is known about the risk factors associated with neurological disorders, the majority of which are incurable and typically worsen over time.

For the study, researchers analyzed data for 678,000 adults between the ages of 45 and 84 who lived in Metro Vancouver from 1994 to 1998 and during a follow-up period from 1999 to 2003.
They estimated individual exposures to road proximity, air pollution, noise and greenness at each person's residence using postal code data.
During the follow-up period, the researchers identified 13,170 cases of non-Alzheimer's dementia, 4,201 cases of Parkinson's disease, 1,277 cases of Alzheimer's disease and 658 cases of multiple sclerosis.

For non-Alzheimer's dementia and Parkinson's disease specifically, living near major roads or a highway was associated with 14% and 7% increased risk of both conditions, respectively.
Due to relatively low numbers of Alzheimer's and multiple sclerosis cases in Metro Vancouver compared to non-Alzheimer's dementia and Parkinson's disease, the researchers did not identify associations between air pollution and increased risk of these two disorders.
However, they are now analyzing Canada-wide data and are hopeful the larger dataset will provide more information on the effects of air pollution on Alzheimer's disease and multiple sclerosis.

When the researchers accounted for green space, they found the effect of air pollution on the neurological disorders was mitigated.
The researchers suggest that this protective effect could be due to several factors.
For people who are exposed to a higher level of green space, they are more likely to be physically active and may also have more social interactions. There may even be benefits from just the visual aspects of vegetation. ( Xagena )

Source: University of British Columbia, 2020

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