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Novel therapeutic options with improved efficacy and safety profiles are needed for the prophylaxis of migraine. In recent years, the inhibition of calcitonin gene-related peptide ( CGRP ) signaling ...


A meta-analysis of phase III, randomised, placebo-controlled trials has assessed the benefits and harms of Pregabalin ( Lyrica ) in the management of neuropathic pain in adults aged 18 years and above ...


There are increasing data that delaying starting disease-modifying drugs and/or routinely stopping all disease-modifying drugs prepregnancy or immediately postconception is associated with increased r ...


Chronic migraine and episodic migraine are clinically, functionally, and anatomically differentiated, with evidence suggesting that they may be separate conditions. Furthermore, patients with chroni ...


Calcitonin gene‐related peptide ( CGRP ) plays an important role in migraine pathophysiology. Eptinezumab, a humanized, anti‐CGRP monoclonal antibody with 100% bioavailability following intravenous a ...


The humanized monoclonal antibody Galcanezumab ( Emgality ), which binds to calcitonin gene‐related peptide ( CGRP ), has been evaluated for migraine prevention. The aim of the post‐hoc analyses w ...


New investigational data from a late-stage study has shown that Teriflunomide ( Aubagio ) significantly slows whole brain volume loss ( atrophy ) compared with placebo in patients with a first clinic ...


Brain injury after non-fatal cardiac arrest Cardiac arrest occurs in two different settings, in-hospital and out-of-hospital, with completely different prognosis, for obvious reasons. As cardiac ...


Multiple sclerosis ( MS ) is a chronic neuroinflammatory condition of the central nervous system ( CNS ). It is a major cause of neurological disability in young adults, particularly women. What trig ...


Combining medication that lowers blood pressure with medication that lowers cholesterol reduced first-time strokes by 44%, according to research presented at the American Stroke Association's Internat ...


The objective of a study was to investigate the kinetics and metabolism of Caffeine in serum from patients with Parkinson disease and controls using liquid chromatography–mass spectrometry. Levels ...


Fremanezumab ( ‎Ajovy ) is a monoclonal antibody directed against calcitonin-gene-related peptide ( CGRP ), a validated target for migraine preventive therapy. In two previous phase 2 studies, Frema ...


Teriflunomide ( Aubagio ) has a well characterized safety and tolerability profile that is consistent across phase II and III studies in the Teriflunomide clinical development program. Overall, adv ...


For the first time, researchers have found a connection between abnormalities in how the brain breaks down glucose and the severity of the signature amyloid plaques and tangles in the brain, as well a ...


There is increasing evidence that links perturbed sphingolipid metabolism to a range of different neurodegenerative conditions including Huntington’s disease ( HD ). Researchers have consolidated t ...