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People who report an elevated number of depression symptoms may be more likely to have a stroke years later than people with no depression symptoms or a low number of depression symptoms, according to ...


Current guidelines recommend lowering cholesterol for heart disease risk reduction. New findings have indicated that if cholesterol dips too low, it may boost the risk of hemorrhagic stroke. Over a ...


Ocrelizumab ( Ocrevus ) is a CD20+ B cell-selective monoclonal antibody approved for treatment of relapsing multiple sclerosis ( RMS ) and primary progressive multiple sclerosis ( PPMS ). Ocrelizum ...


Ocrelizumab ( Ocrevus ) is an infusible humanized monoclonal antibody that selectively depletes CD20+ B cells. Infusion-related reactions ( IRRs ) were summarized from the OPERA I, OPERA II, and ORA ...


Ocrelizumab ( Ocrevus ) was approved for the treatment of relapsing multiple sclerosis ( RMS ) and primary progressive multiple sclerosis ( PPMS ) by the FDA ( US Food and Drug Administration ) in Mar ...


The aim of the study was to evaluate whether Fingolimod [ Gilenya ] ( 0.5 mg and 0.25 mg ) has superior efficacy compared to Glatiramer acetate 20 mg in reducing disease activity over 12 months in pat ...


A study has evaluated the efficacy, safety, and tolerability of Atogepant versus placebo in a phase 2b/3 trial for prevention of episodic migraine. Atogepant is a novel, oral CGRP receptor antagoni ...


Novel therapeutic options with improved efficacy and safety profiles are needed for the prophylaxis of migraine. In recent years, the inhibition of calcitonin gene-related peptide ( CGRP ) signaling ...


A meta-analysis of phase III, randomised, placebo-controlled trials has assessed the benefits and harms of Pregabalin ( Lyrica ) in the management of neuropathic pain in adults aged 18 years and above ...


There are increasing data that delaying starting disease-modifying drugs and/or routinely stopping all disease-modifying drugs prepregnancy or immediately postconception is associated with increased r ...


Chronic migraine and episodic migraine are clinically, functionally, and anatomically differentiated, with evidence suggesting that they may be separate conditions. Furthermore, patients with chroni ...


Calcitonin gene‐related peptide ( CGRP ) plays an important role in migraine pathophysiology. Eptinezumab, a humanized, anti‐CGRP monoclonal antibody with 100% bioavailability following intravenous a ...


The humanized monoclonal antibody Galcanezumab ( Emgality ), which binds to calcitonin gene‐related peptide ( CGRP ), has been evaluated for migraine prevention. The aim of the post‐hoc analyses w ...


New investigational data from a late-stage study has shown that Teriflunomide ( Aubagio ) significantly slows whole brain volume loss ( atrophy ) compared with placebo in patients with a first clinic ...


Brain injury after non-fatal cardiac arrest Cardiac arrest occurs in two different settings, in-hospital and out-of-hospital, with completely different prognosis, for obvious reasons. As cardiac ...